Diseases and Conditions

Peripheral artery disease (PAD)

Risk factors

Factors that increase your risk of developing peripheral artery disease include:

  • Smoking
  • Diabetes
  • Obesity (a body mass index over 30)
  • High blood pressure
  • High cholesterol
  • Increasing age, especially after age 65 or after 50 if you have risk factors for atherosclerosis
  • A family history of peripheral artery disease, heart disease or stroke
  • High levels of homocysteine, an amino acid that helps your body make protein and to build and maintain tissue

People who smoke or have diabetes have the greatest risk of developing peripheral artery disease due to reduced blood flow.